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Keratin 5-Cre-driven deletion of

Jun Yang, Lianqing Wang, Yingzhi Huang, Keqiang Liu, Chaoxia Lu, Nuo Si, Rongrong Wang, Yaping Liu, Xue Zhang

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 305-317 doi: 10.1007/s11684-019-0722-8

Abstract: from postnatal day 0 (P0), and this increase occurred much earlier than those of TNF- , IL-23A, IL-1RNA-Seq analysis indicated that Sprr2d, a member of the small proline-rich protein 2 family, in the skin

Keywords： acne inversa mouse model     interleukin 1 family     member 6     small proline rich protein 2D     key inflammatory    

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Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 217-226 doi: 10.1007/s11684-014-0326-2

Abstract: designed to investigate the contribution of miRNA-122-binding site polymorphism at the IL-1A

Keywords： hepatocellular carcinoma (HCC)     interaction     miRNA-122-binding site     IL-1A     rs3783553     hepatitis B virus (    

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Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 139-145 doi: 10.1007/s11684-015-0377-z

Abstract: In this review article, interleukin 15 (IL-15) is used as a new example to explain the beneficial effectsdifferent subunits (α, β and γ) to activate JAK/STAT, PI3K/Akt, IKK/NF-κB and JNK/AP1

Keywords： inflammation     obesity     cytokine     energy expenditure     insulin resistance    

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Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1): A Multifaceted Cell Survival Factor that Review

Tamana Yousof, Jae Hyun Byun, Jack Chen, Richard C. Austin

Engineering 2023, Volume 20, Issue 1,   Pages 9-18 doi: 10.1016/j.eng.2022.05.014

Abstract:

Pleckstrin homology-like domain, family A, member 1 (PHLDA1) is a multifaceted intracellular proteinbelonging to the evolutionarily conserved pleckstrin homology-related domain family.In recent years, PHLDA1 has received increased attention due to its association with obesity, fatty liverIn this review, the current knowledge of PHLDA1 gene and protein regulation, localization, andThis review highlights the pro- and anti-apoptotic roles of PHLDA1 that contribute to vast array of metabolic

Keywords： ER-stress     Metabolism     Apoptosis     Cell survival     PHLDA1    

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Epidemiological study of a von Hippel-Lindau family in northwest China

Jingyao Zhang, Dapeng Wu, Hong Ai, Jigang Bai, Shunbin Dong, Qinling Yang, Kai Qu, Lei Zhou, Xinsen Xu, Chang Liu

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 378-385 doi: 10.1007/s11684-013-0276-0

Abstract: We encountered a large VHL family in northwest China and conducted a systematic screening of the familyFor the preliminary family screening, physical examination and abdomen B ultrasonography were performedA total of 63 lineal descendants in six generations were observed in the family (generations O, A, B,Among the 10 living cases, 4, 2, 1, 3, 4, 8, and 2 manifested HBLs of the CNS, PETs, RCC, pancreaticTherefore, follow-up checkups of the family should be focused on younger generations.

Keywords： von Hippel-Lindau disease     epidemiology     family screening     pancreatic endocrine tumor    

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The Advanced Gun Family——the birth of type 95 (5.8 mm) squad gun family

Duo Yingxian

Strategic Study of CAE 1999, Volume 1, Issue 2,   Pages 57-61

Abstract: So after a short period of cooperated work, a new advanced squad gun family has been developed basedThis guns family were already used to equip the army assigned to Hong Kong in January, 1997 and shall

Keywords： squad gun family     automatic rifle     machine rifle     assault rifle    

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Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic

Frontiers of Medicine   Pages 1006-1009 doi: 10.1007/s11684-023-1000-3

Abstract: Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic

Keywords： family craniofacial microsomia     Identification novel mutations    

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Family planning technical services in China

Shang-Chun WU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 285-289 doi: 10.1007/s11684-010-0097-3

Abstract: Family planning is a basic state policy in China.Technical services are the key measures for implementing the family planning policy.appropriate contraceptive methods based on the government’s commitment, China has established countrywide family

Keywords： family planning     contraceptive method     service delivery    

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murine pancreatic carcinoma by β-elemene combined with dendritic cells modified with genes encoding interleukin

TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 41-45 doi: 10.1007/s11684-007-0008-4

Abstract: The dendritic cell vaccine is a treatment vaccine with potent clinical applications. Functional cytokines can enhance dendritic cell anti-tumor immune responses. This experiment was conducted to study the effects of bone marrow-deriv

Keywords： Functional     experiment     anti-tumor     dendritic     clinical    

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Discussion on the view of feeding patterns in new era’s family planning services

Yan Xiaoqing

Strategic Study of CAE 2014, Volume 16, Issue 5,   Pages 24-30

Abstract: analyzes general reference volume，the impact of feeding-related factors as well as grass-roots demand for familyexplores the scientific and standardized service examination and evaluation system，enhances the grassroots family

Keywords： feeding patterns     statistical analysis     family planning services    

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SUPEROXIDE DISMUTASE FAMILY GENES IN WATERMELON AND THEIR RESPONSES TO DIFFERENT ABIOTIC STRESSES

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 4,   Pages 645-658 doi: 10.15302/J-FASE -2020350

Abstract: Genome-wide analysis of the SOD gene family in various plant species has been conductedbut little is known about this gene family in watermelon (Citrullus lanatus).nbsp;SOD genes were identified in the watermelon genome and are designated ClCSD1-5, ClFSD1-2 and ClMSD according to their metal cofactors.

Keywords： abiotic stress / expression analysis / phylogeny / SOD / superoxide dismutase / watermelon    

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A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 330-338 doi: 10.1007/s11684-022-0933-2

Abstract: Clouston syndrome (OMIM #129500), also known as hidrotic ectodermal dysplasia type 2, is a rare autosomal dominant skin disorder. To date, four mutations in the GJB6 gene, G11R, V37E, A88V, and D50N, have been confirmed to cause this condition. In previous studies, the focus has been mainly on gene sequencing, and there has been a lack of research on clinical manifestations and pathogenesis. To confirm the diagnosis of this pedigree at the molecular level and summarize and analyse the clinical phenotype of patients and to provide a basis for further study of the pathogenesis of the disease, we performed whole-exome and Sanger sequencing on a large Chinese Clouston syndrome pedigree. Detailed clinical examination included histopathology, hair microscopy, and scanning electron microscopy. We found a novel heterozygous missense variant (c.134G>C:p.G45A) for Clouston syndrome. We identified a new clinical phenotype involving all nail needling pain in all patients and found a special honeycomb hole structure in the patients’ hair under scanning electron microscopy. Our data reveal that a novel variant (c.134G>C:p.G45A) plays a likely pathogenic role in this pedigree and highlight that genetic testing is necessary for the diagnosis of Clouston syndrome.

Keywords： Clouston syndrome     whole exome sequencing     GJB6 gene     novel variant     unique phenotype    

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Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function

Frontiers of Medicine doi: 10.1007/s11684-023-1006-x

Abstract: Here, a Pakistani family with parental consanguinity was presented, characterized with severe intellectual

Keywords： neurodevelopmental disorder     autosomal recessive intellectual disability     consanguinity     spastic paraplegia     hearing loss     TMEM141    

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proteins reveals a novel human gene, LY6A, which encodes the candidate ortholog of mouse Ly-6A/Sca-1

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 458-475 doi: 10.1007/s11684-022-0968-4

Abstract: The Ly-6 and uPAR (LU) domain-containing proteins represent a large family of cell-surface markers.In particular, mouse Ly-6A/Sca-1 is a widely used marker for various stem cells; however, its human orthologwe identified a previously unannotated human gene encoding the candidate ortholog of mouse Ly-6A/Sca-1.Similar to mouse Ly-6A/Sca-1, human LY6A is also upregulated by interferon, suggesting a conservedsequence, domain architecture, and exon‒intron structures are all well conserved with mouse Ly-6A/Sca-1.

Keywords： LU domain-containing protein family     novel human gene     LY6A     pituitary tumor     biomarker     nonsynonymous    

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Genetic association between the polymorphism of cytosolic PLA2 gene family and schizophrenia

Qiong YU PhD, Xiang-Fei MENG PhD, Jie-Ping SHI, Ya-Qin YU PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 101-105 doi: 10.1007/s11684-010-0017-6

Abstract: investigate the genetic association between the polymorphism of cytosolic phospholipase A2 (cPLA2) familyreaction (PCR-LDR) was applied to detect the genotype ten single nucleotide polymorphisms (SNPs) of cPLA2 familyOur data suggest that many loci in the cPLA2 family genes may be associated with schizophrenia.

Keywords： schizophrenia     cytosolic phospholipase A2     ligase detection reaction     polymorphism    

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Title Author Date Type Operation

Keratin 5-Cre-driven deletion of

Jun Yang, Lianqing Wang, Yingzhi Huang, Keqiang Liu, Chaoxia Lu, Nuo Si, Rongrong Wang, Yaping Liu, Xue Zhang

Journal Article

Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Journal Article

Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Journal Article

Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1): A Multifaceted Cell Survival Factor that

Tamana Yousof, Jae Hyun Byun, Jack Chen, Richard C. Austin

Journal Article

Epidemiological study of a von Hippel-Lindau family in northwest China

Jingyao Zhang, Dapeng Wu, Hong Ai, Jigang Bai, Shunbin Dong, Qinling Yang, Kai Qu, Lei Zhou, Xinsen Xu, Chang Liu

Journal Article

The Advanced Gun Family——the birth of type 95 (5.8 mm) squad gun family

Duo Yingxian

Journal Article

Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic

Journal Article

Family planning technical services in China

Shang-Chun WU

Journal Article

murine pancreatic carcinoma by β-elemene combined with dendritic cells modified with genes encoding interleukin

TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo

Journal Article

Discussion on the view of feeding patterns in new era’s family planning services

Yan Xiaoqing

Journal Article

SUPEROXIDE DISMUTASE FAMILY GENES IN WATERMELON AND THEIR RESPONSES TO DIFFERENT ABIOTIC STRESSES

Journal Article

A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome

Journal Article

Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function

Journal Article

proteins reveals a novel human gene, LY6A, which encodes the candidate ortholog of mouse Ly-6A/Sca-1

Journal Article

Genetic association between the polymorphism of cytosolic PLA2 gene family and schizophrenia

Qiong YU PhD, Xiang-Fei MENG PhD, Jie-Ping SHI, Ya-Qin YU PhD,

Journal Article